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Diabetes, keeping blood glucose levels steady is the name of the game.
In addition, hepatocytes, but not cells, express a specific GCK inhibitory protein.
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Additional testing can then be ordered to confirm the diagnosis.
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These data enabled Vulliamy et al to suggest an evolutionary pathway for the different mutations, with only a single ambiguity.
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A 6 month extension phase of the study may provide some insights in this regard.
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I followed this type of one size fits all advice and created a serious additional problem.